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Structural-function Discovery Laboratory

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Publications

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Endogenous formation of phosphatidylhomoserine in Escherichia coli through phosphatidylserine synthase

Endogenous formation of phosphatidylhomoserine in Escherichia coli through phosphatidylserine synthase
  • AuthorElise Zi Qi Ng, Eunju Lee, Shu-Sin Chng, Jungwook Kim, Xue Li Guan
  • Year2025
  • SourceJournal of Biological Chemistry. 2025 May 20:110255. doi: 10.1016/j.jbc.2025.110255.
Structural basis for membrane association and catalysis by phosphatidylserine synthase in Escherichia coli

Structural basis for membrane association and catalysis by phosphatidylserine synthase in Escherichia coli
  • AuthorEunju Lee, Gyuhyeok Cho, and Jungwook Kim
  • Year2024
  • SourceScience Advances. 2024 Dec 20;10(51):eadq4624. doi: 10.1126/sciadv.adq4624.
Structural insights into phosphatidylethanolamine N-methyltransferase PmtA mediating bacterial phosphatidylcholine synthesis

Structural insights into phosphatidylethanolamine N-methyltransferase PmtA mediating bacterial phosphatidylcholine synthesis
  • AuthorSalma D. Salsabila and Jungwook Kim
  • Year2024
  • SourceScience Advances. 2024 Oct 4;10(40):eadr0122. doi: 10.1126/sciadv.adr0122.
Structural basis for the selective methylation of 5-carboxymethoxyuridine in tRNA modification

Structural basis for the selective methylation of 5-carboxymethoxyuridine in tRNA modification
  • AuthorJaehun Yoo, Jangmin Lee, and Jungwook Kim
  • Year2023
  • SourceNucleic Acids Research. 2023 Sep 22;51(17):9432-9441. doi: 10.1093/nar/gkad668.
Identification of a novel 5-aminomethyl-2-thiouridine methyltransferase in tRNA modification

Identification of a novel 5-aminomethyl-2-thiouridine methyltransferase in tRNA modification
  • AuthorGyuhyeok Cho†, Jangmin Lee†, and Jungwook Kim (†Co-first author)
  • Year2023
  • SourceNucleic Acids Research. 2023 Feb 28;51(4):1971-1983. doi: 10.1093/nar/gkad048.
Structural and functional characterization of TrmM in m6A modification of bacterial tRNA

Structural and functional characterization of TrmM in m6A modification of bacterial tRNA
  • AuthorHyeonju Jeong, Yeji Lee and Jungwook Kim
  • Year2022
  • SourceProtein Science. 2022 May;31(5):e4319. doi: 10.1002/pro.4319
Unique anticodon loop conformation with the flipped-out wobble nucleotide in the crystal structure of unbound tRNAVal

Unique anticodon loop conformation with the flipped-out wobble nucleotide in the crystal structure of unbound tRNAVal
  • AuthorHyeonju Jeong and Jungwook Kim
  • Year2021
  • SourceRNA. 2021 Jul 27;rna.078863.121. doi: 10.1261/rna.078863.121
Structural insights into phosphatidylethanolamine formation in bacterial membrane biogenesis

Structural insights into phosphatidylethanolamine formation in bacterial membrane biogenesis
  • AuthorGyuhyeok Cho, Eunju Lee and Jungwook Kim
  • Year2021
  • SourceScientific Reports. 2021 Mar 11;11(1):5785. doi: 10.1038/s41598-021-85195-5
Structural snapshots of CmoB in various states during wobble uridine modification of tRNA

Structural snapshots of CmoB in various states during wobble uridine modification of tRNA
  • AuthorSehwang Jeong and Jungwook Kim
  • Year2021
  • SourceBiochemical and Biophysical Research Communications. 2021 Jan 1;534:604-609. doi: 10.1016/j.bbrc.2020.11.033
Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds

Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds
  • AuthorJihoon Kang, Haushabhau S. Pagire, Donguk Kang, Yo Han Song, In Kyu Lee, Kang Taek Lee, Chin-Ju Park, Jin Hee Ahn, and Jungwook Kim
  • Year2020
  • SourceBiochemical and Biophysical Research Communications. 2020 Jun 30;527(3):778-784. doi: 10.1016/j.bbrc.2020.04.102
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